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| Hydroxycoumarin 4-methylumbelliferone, also known as hydroxycoumarin or bile duct, is a new type of choleretic drug, belonging to coumarin derivatives. It is a white or almost white crystalline powder at room temperature, odorless, and tasteless. Insoluble in water, slightly soluble in methanol and ethanol, easily soluble in sodium hydroxide solution, has a relaxing effect on the bile duct sphincter muscle, strong antispasmodic and analgesic effects, and can also gently and continuously promote bile secretion, strengthen gallbladder contraction and antibacterial effects. It has a significant beneficial effect on the gallbladder and has a certain stone expulsion effect on common bile duct stones. It can also reduce liver enzymes and restore them to normal. Clinically, it is mainly used for cholecystitis, biliary tract infection, gallstones, and postoperative biliary syndrome. Some patients with elevated levels of alanine aminotransferase may recover to normal after taking medication with the elimination of inflammation. Some may experience dizziness, bloating, chest tightness, rash, diarrhea, etc., which disappear on their own after discontinuing the medication. High doses can cause excessive secretion of bile and diarrhea. Use with caution in patients with obstructive and infectious jaundice hepatitis. | |||||||||
90-33-5
futurechemical
90-33-5
4-Methylumbelliferone Basic information | |
Product Name: | 4-Methylumbelliferone |
CAS: | 90-33-5 |
MF: | C10H8O3 |
MW: | 176.17 |
EINECS: | 201-986-7 |
Mol File: | 90-33-5.mol |
4-Methylumbelliferone Chemical Properties | |
Melting point | 188.5-190 °C(lit.) |
Boiling point | 267.77°C (rough estimate) |
density | 1.1958 (rough estimate) |
refractive index | 1.5036 (estimate) |
storage temp. | 2-8°C |
solubility | Practically insoluble in water; slightly soluble in ethanol, ether,chloroform; soluble inmethanol |
pka | 7.79(at 25℃) |
form | Crystalline Powder |
color | off-white to yellow |
PH Range | Green 1 uorescent (0.0) to weak blue 1 uorescent (2.0);Weak blue 1 uorescent (6.5) blue 1 uorescent (8.0) |
Water Solubility | slightly soluble |
λmax | 221nm, 251nm, 322nm |
BRN | 142217 |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
Major Application | color filter, electroluminescent displays, document security processes, lasers, integrated circuits, liquid crystal displays, surface brightening composition, oil products, teeth whitening agent, lysosomal enzyme assay, substrate for lipase, determining protein-protein-interactions in living cells, Antitrypanosomal, antileishmanial, anticancer, antiHIV, antimalarial, antibacterial, antifungal |
InChI | 1S/C10H8O3/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5,11H,1H3 |
InChIKey | HSHNITRMYYLLCV-UHFFFAOYSA-N |
SMILES | CC1=CC(=O)Oc2cc(O)ccc12 |
LogP | 2.370 (est) |
CAS DataBase Reference | 90-33-5(CAS DataBase Reference) |
NIST Chemistry Reference | Coumarin, 7-hydroxy-4-methyl-(90-33-5) |
EPA Substance Registry System | 4-Methylumbelliferone (90-33-5) |
