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| Glycyrrhizic acid is a pale yellow powder with a sweet, slightly bitter taste, containing 6%–14% glycyrrhizic acid. Pure glycyrrhizic acid is a crystalline powder with an extremely sweet taste, 200–250 times sweeter than sucrose, and the sweetness lingers for a long time. Its melting point is 212–217℃. It is readily soluble in hot water, insoluble in ether, and sparingly soluble in propylene glycol and ethanol. It is stable to heat, alkalis, and salts; precipitation will occur in the solution at pH 5.4 or below 3. The oral LD50 in mice is greater than 10 g/kg. The ADI (Advanced Individual Intake) is determined by delay (FAO/WHO, 1994). | |||||||||
1405-86-3
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1405-86-3
Glycyrrhizic acid Basic information | |
Product Name: | Glycyrrhizic acid |
CAS: | 1405-86-3 |
MF: | C42H62O16 |
MW: | 822.94 |
EINECS: | 215-785-7 |
Mol File: | 1405-86-3.mol |
Glycyrrhizic acid Chemical Properties | |
Melting point | 220°C (rough estimate) |
alpha | D17 +46.2° (c = 1.5 in alc) |
Boiling point | 681.01°C (rough estimate) |
density | 1.1442 (rough estimate) |
refractive index | 61 ° (C=1.5, EtOH) |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | DMSO (Slightly), Ethanol (Slightly), Methanol (Sparingly), Pyridine (Slightly) |
form | Solid |
pka | 2.76±0.70(Predicted) |
color | White to Light Yellow |
Odor | at 100.00 %. mild spicy |
Odor Type | spicy |
Merck | 144,505 |
Stability: | Hygroscopic |
Major Application | pharmaceutical (small molecule) |
Cosmetics Ingredients Functions | SKIN CONDITIONING |
HUMECTANT | |
Cosmetic Ingredient Review (CIR) | Glycyrrhizic acid (1405-86-3) |
InChIKey | BXFBITNYMHAJGT-KYXJNIQISA-N |
LogP | 4.64 |
CAS DataBase Reference | 1405-86-3 |
EPA Substance Registry System | Glycyrrhizin (1405-86-3) |
Analysis 分析 | Specification规格 | Results 结果 |
Assay 含量（UV） | ≥95% | 98.5% |
【Identification】/【鉴别】 The physical and chemical理化鉴别 | Positive reaction 应呈正反应 | Complies 合格 |
Appearance 性状 | White crystalline powder | Complies 合格 |
Ash 灰份 | ≤1.0% | 0.5% |
Moisture 水份 | ≤6.0% | 3.8% |
Heavy metals 重金属 | ≤20ppm | Complies 合格 |
As 砷 | ≤2.0ppm | Complies 合格 |
Odor 气味 | Characteristic 特殊气味 | Complies 合格 |
Particle size 粒度 | 100%through 80 mesh | Complies 合格 |
Microbioiogical 微生物指标： | ||
Total of bacteria 细菌总数 | ≤1000cfu/g | Complies 合格 |
Fungi 霉菌 | ≤100cfu/g | Complies 合格 |
Salmgosella 沙门氏菌 |  Negative 无 | Complies 合格 |
Coli 大肠杆菌 | Negative 无 | Complies 合格 |
