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| Synonyms:Alpha-KG /AKG 2-Oxopentanedioic acid Oxoglutaric acid 2-Oxoglutarate Molecular Formula:C5H6O5 Molecular Weight: 146.1 HS Code: 2918300090 Grade:Enterprise Standards99% Hazard Class:General Cargo | |||||||||
328-50-7
bosschem
328-50-7
2-Ketoglutaric acid (α-ketoglutaric acid, AKG; CAS 328-50-7) is a white to pale-yellow crystalline keto acid that sits at the metabolic crossroads of every living cell. It is the central intermediate of the citric acid (Krebs) cycle, the hub of amino-acid transamination, and a key link between carbon, nitrogen and energy metabolism. The compound melts near 114–115 °C and dissolves readily in water (about 100 g/L at 20 °C). Beyond its biological roles, commercial AKG serves three main markets: as an ingredient in sports nutrition and health supplements (including ornithine α-ketoglutarate and amino-acid formulas), as a flavoring agent approved for food use
Core value propositions:
● Metabolic Hub Molecule: central intermediate of the citric acid cycle and amino-acid transamination;
● Nutrition & Supplement Ingredient: supports sports-nutrition, amino-acid
● Food-Grade Flavoring: approved flavoring agent/adjuvant in food applications;
● Multi-Grade Supply: feed, food, nutrition and reagent grades to match your application.
Item | Specification |
Chemical Name | 2-Oxopentanedioic acid (2-ketoglutaric acid) |
Synonyms | α-Ketoglutaric acid; 2-oxoglutaric acid; oxogluric acid; AKG; Oxoglurate |
CAS No. | 328-50-7 |
EC No. (EINECS) | 206-330-3 |
Molecular Formula | C₅H₆O₅ |
Molecular Weight | 146.10 g/mol |
Appearance | White to pale-yellow crystalline powder |
Solubility | Soluble in water (≈ 100 g/L at 20 °C); soluble in ethanol and methanol |
2-Ketoglutaric acid is a five-carbon dicarboxylic acid carrying a ketone group at the carbon adjacent to one carboxyl — the defining α-keto acid arrangement. Its two carboxylic acid groups dissociate progressively with pH, and the α-keto carbonyl makes the molecule reactive toward amines and oxidants. It melts at about 114–115.5 °C and dissolves readily in water (about 100 g/L at 20 °C) and lower alcohols. It is also the acceptor of amino groups in transamination: glutamate dehydrogenase and transaminases convert it to glutamate, which is how excess ammonia is trapped and routed to the urea cycle, and the reverse reactions build glutamine, proline, arginine and lysine. As a non-enzymatic antioxidant it reacts directly with hydrogen peroxide (decarboxylating to succinate, CO₂ and water) and supports superoxide dismutase activity, and as a cofactor substrate for Fe²⁺/α-ketoglutarate-dependent dioxygenases (including TET enzymes) it participates in epigenetic and oxygen-sensing biochemistry.
● Cntral metabolic intermediate: connects the citric acid cycle, amino acid metabolism and nitrogen balance.
● Non-enzymatic antioxidant – removes hydrogen peroxide and assists superoxide dismutase in its function.
● Purity: material with full COA.
● Good water solubility (~100 g/L at 20 °C) for clean formulation and dosing.
As a central metabolic intermediate, AKG is a widely used ingredient in sports and health nutrition:
● Sports nutrition: helps in recovery and muscle protein synthesis in formulas for post-exercise and training.
● Amino-acid complexes: component of ornithine α-ketoglutarate (OKG) and other keto-acid mixtures.
● ● Animal nutrition: nutritional feed additive for growth and metabolic support in livestock and aqua culture
Naturally present in living systems, α-ketoglutaric acid is approved as a food flavoring ingredient:
● Flavoring agent/adjuvant in food products (accepted for flavor use).
● Flavor-modulating component in beverages and specialty foods.
● Nutritional fortification of functional foods and sports drinks.
Its antioxidant and metabolic activity has brought AKG into skincare research:
● Antioxidant skincare: hydrogen-peroxide scavenging and SOD-supporting activity in formulation research.
● Anti-aging cosmetic actives research.
Additional established uses:
● Biochemical reagent: transaminase substrate and metabolic research standard.
● Fine-chemical intermediate for specialty keto-acid derivatives.
● Agricultural and plant-physiology research.
Packaging (customizable):
● 25 kg fiber drums or multi-wall paper bags with PE liner;
● small trial orders welcome;
Storage:
● Store in a cool, dry, well-ventilated area; keep containers tightly closed.
● Protect from moisture and direct sunlight; keep away from strong oxidizers.
● Avoid dust generation during handling.
Handling & Safety (per SDS):
● Wear chemical goggles, protective gloves and dust protection when handling;
● On eye contact, rinse immediately with plenty of water and seek medical attention.
● Factory-direct supply: own production and sourcing capability, transparent pricing, no middleman markup.
● Stable quality: strict internal control; every batch tested (assay, appearance, solubility), COA with every shipment.
● Fast response: quotations and technical support (COA, SDS, application advice); small trial orders accepted.
2-Ketoglutaric acid (α-ketoglutaric acid, AKG) is used in three main markets: as a sports-nutrition and health-supplement ingredient (including ornithine α-ketoglutarate and amino-acid formulas), as an approved food flavoring agent, and as a high-purity biochemical reagent for biomedical, cosmetic and biotech R&D. All of these uses trace back to its role as a central intermediate of the citric acid cycle and amino-acid metabolism.
As a substance naturally present in metabolism, α-ketoglutaric acid has an established safety profile: it is accepted for use as a flavoring agent in food, and it is widely used in dietary and sports-nutrition supplements. Handle the raw powder with standard precautions — it is classified as an eye irritant (GHS H318) with possible skin and respiratory irritation, so goggles, gloves and dust control are recommended. As with any supplement ingredient, finished-product claims and dosage should follow applicable regulations in the target market.
AKG is a common ingredient in sports-nutrition formulas because of its role in amino-acid and energy metabolism. It is often supplied as ornithine α-ketoglutarate (OKG) or blended into recovery and amino-acid products, and it has been studied in clinical and post-operative nutrition for supporting muscle protein synthesis.
