 |
Synonyms:p-Dioxane | |||||||||
123-91-1
bosschem
123-91-1
1,4-Dioxane, also known as 1,4-dioxane, is a saturated six-membered ring ether composed of four carbon atoms and two oxygen atoms. It is an important aprotic polar organic solvent in industry. Its chemical formula is usually written as:
C4H8O2 (1,4-dioxane, CAS No.: 123-91-1, molecular weight approximately 88.11)
It is a colorless, transparent liquid at room temperature with a slightly fragrant ester odor. It is miscible with water and most organic solvents. Its boiling point is 101.32℃, freezing point is 11.8℃, relative density is 1.0329, flash point is 5-18℃ (extremely flammable), and refractive index is 1.4175. The solubility of 1,4-dioxane is similar to that of dimethylformamide (DMF) and stronger than that of tetrahydrofuran (THF), and it is known as a "highly polar cyclic ether solvent between diethyl ether and DMF." This cyclic ether can undergo ring-opening reactions and coupling reactions under special conditions. Prolonged storage of 1,4-dioxane may contain peroxides; it should be tested and treated before use.
Structurally, the two oxygen atoms in the 1,4-dioxane molecule are symmetrically distributed on the six-membered ring, giving it excellent polarity, coordination ability, and thermal stability. It can dissolve cellulose esters, various resins, oils and waxes, and many polar organic compounds, making it a "universal solvent" commonly used in industrial synthesis and laboratories.
This product is categorized by application area, commonly including: industrial grade (for resin dissolution, synthetic leather, extraction, and chemical synthesis; common specifications are purity above 99.5%) and reagent grade (for laboratory analysis). Different grades have different purity and impurity control requirements, with particular emphasis on the following indicators:
The moisture content controls the solubility, reaction systems and storage stability and must be kept strictly under control.
Cyclic ethers are prone to oxidation and peroxide formation during long term storage, which alters the reaction, and is also an explosion hazard. Therefore, they should be tested and controlled before use.
Acidity is a measure of the amount of free acid. The stability of the reaction system will be affected by excessive acidity, and it must be controlled within a reasonable range.
The boiling range is an indication of the purity and composition of a product. A narrow boiling range is indicative of high purity which is very important for solvent recovery and reuse applications.
Evaporation residue is the total amount of impurities and is important for precision applications and laboratory analysis and must be controlled in an extremely low range.
The color influences the appearance of the downstream products that are supposed to be colorless and transparent.
1,4-Dioxane, with its unique combination of high polarity, strong solubility, and cyclic ether structure, has wide applications in chemical synthesis, polymer processing, and laboratory fields.
1,4-Dioxane is a highly polar aprotic solvent, used as a reaction medium in some organic chemical synthesis processes such as Grignard reactions, organometallic reactions, and condensation reactions. It helps stabilize reactive intermediates and enhance reaction selectivity and yield.
1,4-Dioxane is a good solvent for cellulose esters, various resins and waxes, and is used as a reaction solvent for polyurethane synthetic leather, amino acid synthetic leather and some polymer processing, so it is one of the important solvents in synthetic leather industry.
1,4-Dioxane is used as a solvent in liquid-liquid extraction for the separation and purification of certain organic compounds, as the separation processes of fine chemicals.
1,4-Dioxane has been historically used as a stabilizer for chlorinated solvents, such as 1,1,1-trichloroethane, to inhibit decomposition of chlorinated solvents and corrosion of metal containers. It is a textbook application in the stabilization of chlorinated hydrocarbons.
It is used as a reaction solvent in the synthesis of pesticides and fine chemicals, helping to improve reaction efficiency and product purity.
1,4-Dioxane is used as a co-solvent in oils, waxes, coatings and cleaning formulations to improve solubility and formulation compatibility.
Reagent-grade 1,4-dioxane is used as a laboratory solvent for chromatographic analysis, spectroscopic analysis, and organic synthesis. It is also a standard and reaction medium for some analytical projects and is a commonly used reagent in scientific research laboratories.
Reagent-grade 1,4-dioxane is used as a reaction medium in laboratory organic synthesis (such as Grignard reaction, organometallic reaction, condensation reaction) to help stabilize reactive intermediates and improve reaction selectivity and yield.
Including solvent carriers for special reactions and organic synthesis research, with the progress of green solvent replacement, 1,4-dioxane is being replaced by more environmentally friendly solvents in some scenarios, and its application scope is generally becoming more standardized.
1,4-Dioxane (C4H8O2, CAS No. 123-91-1) is a clear, colorless liquid that is miscible with water and most organic solvents. It is an important aprotic solvent in chemical synthesis, polymer processing and laboratory applications due to its high polarity, strong solubility and cyclic ether structure. In our everyday lives we mostly encounter it as trace impurities in shampoos, shower gels and other personal care products, as well as in drinking water environmental monitoring. In applications 1,4-dioxane is widely used as a highly polar reaction solvent, a solvent for resins and synthetic leather, an extractant, a stabilizer for chlorinated solvents, in the synthesis of pesticides and fine chemicals and as a laboratory analytical reagent.
